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Low-dimensional compounds containing bioactive ligands. Part XV: Antiproliferative activity of tris(5-nitro-8-quinolinolato)gallium(III) complex with noticeable selectivity against the cancerous cells.

Autoři: Litecká M., Prachařová J., Kašpárková J., Brabec V., Smolková R., Gyepes R., Obuch J., Kubíček V., Potočňák I.Publikováno : Polyhedron 187, 114672Rok: 2020

Three gallium(III) complexes, [Ga(NQ)3] (1), Na3[Ga(SQ)3]·7H2O·3NaCl (2) and [Ga(ClNQ)3]·MeOH (3) were synthesised as possible anticancer agents (H-NQ = 5-nitro-8-quinolinol, H-SQH = 5-sulfo-8-quinolinol, H-ClNQ = 5-chloro-7-nitro-8-quinolinol) and characterised by elemental analysis, IR and NMR spectroscopy. Single crystal structure analysis of 1 revealed two crystallographically independent [Ga(NQ)3] molecules in the asymmetric part of the unit cell. Stability of the complexes 1 and 2 in solution was determined by 1H NMR spectroscopy. Complex 3 was not further studied due to the low solubility. Antiproliferative activity of complexes 1 and 2 was studied using in vitro MTT assay against the A2780, HCT116 and MDA-MB-231 cancer cell lines and the selectivity of the complexes was verified on noncancerous MRC5 pd30 cell line. Complex 1 showed high antiproliferative potency (IC50 = 3.6 ± 0.8 μm for HCT116) and noticeable selectivity of 1 against the cancerous cancer cell lines (IC50 = 32 ± 4 μm for normal MRC5 pd30 cell line) was also found. The complex 2 displayed the highest antioxidant activity of all tested complexes and free ligands.


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